Retroviral vectors have induced subtle clonal skewing in many gene therapy patients and severe clonal proliferation and leukemia in some of them, emphasizing the need for comprehensive integration ...

The risk of second tumors after chimeric antigen receptor (CAR) T-cell therapy, especially the risk of T-cell neoplasms related to viral vector integration, is an emerging concern. A total of 724 ...

Scientists have eliminated the need for a viral vector in the stem cell reprogramming process In a report in Science, they showed the ability to reprogram adult cells into iPS cells without viral ...